Table 3.
All AEs, regardless of attribution
| Grade | 1 | 2 | 3 | 4 | Total |
|---|---|---|---|---|---|
| Symptom | |||||
| Pain (all types) | 2 | 2 | 2 | – | 6 |
| Cough | 1 | 1 | – | – | 2 |
| Dyspnea | – | – | 2 | – | 2 |
| Pneumonia | – | – | 2 | – | 2 |
| Vomiting | 1 | 1 | – | – | 2 |
| Chronic leg swelling | 1 | – | – | – | 1 |
| Constipation | 1 | – | – | – | 1 |
| Dehydration | 1 | – | – | – | 1 |
| Depression | – | 1 | – | – | 1 |
| Dermatitis, scalp | 1 | – | – | – | 1 |
| Fall | 1 | – | – | – | 1 |
| Fever | 1 | – | – | – | 1 |
| Flu-like symptoms | 1 | – | – | – | 1 |
| Laryngeal hemorrhage | 1 | – | – | – | 1 |
| Nausea or vomiting | 1 | – | – | – | 1 |
| Papular rash, arm and leg | 1 | – | – | – | 1 |
| Pericardial effusion | – | 1 | – | – | 1 |
| Pulmonary hypertension | – | 1 | – | – | 1 |
| Wheezing | 1 | – | – | – | 1 |
| Laboratory parameter | |||||
| Anemia mean | 3 | 1 | 1 | – | 5 |
| Alkaline phosphatase increased | 2 | – | – | – | 2 |
| Hypercalcemia | – | 1 | 1 | – | 2 |
| ALT increased | – | 1 | – | – | 1 |
| AST increased | – | – | 1 | – | 1 |
| BUN increased | 1 | – | – | – | 1 |
| Cholesterol increased | 1 | – | – | – | 1 |
| Hypoglycemia | 1 | – | – | – | 1 |
| Hypokalemia | – | 1 | – | – | 1 |
| Hyponatremia | 1 | – | – | – | 1 |
| LDH increased | 1 | – | – | – | 1 |
| Leukocytosis | 1 | – | – | – | 1 |
| Phosphorous increased | 1 | – | – | – | 1 |
| Triglycerides increased | 1 | – | – | – | 1 |
Abbreviations: AEs, adverse events; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; LDH, lactate dehydrogenase.