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. 2017 Aug 30;12:6357–6364. doi: 10.2147/IJN.S139167

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© 2017 Mirjolet et al. This work is published and licensed by Dove Medical Press Limited

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TiONts-DTX biodistribution analysis.

Notes: (A) SPECT-CT imaging of kinetics and biodistribution analysis for each organ (expressed as a percentage of injected ¹¹¹In activity, taking into account the decrease in ¹¹¹In activity after the injection of DOTA[¹¹¹In] (A1) or TiONts-DTX-DOTA[¹¹¹In] (A2)). (B) TiONts-DTX-DOTA[¹¹¹In] biodistribution in dissected organs by radioactivity detection using gamma counting 7 days after injection (mean value ± SD). (C) TEM images showing the intracellular location of TiONts-DTX 24 h after injection into PC-3 tumors.

Abbreviations: DTX, docetaxel; SPECT-CT, single-photon emission computed tomography-computed tomography; TEM, transmission electron microscopy; TiONts, titanate nanotubes.