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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: J Am Chem Soc. 2017 Jun 6;139(24):8126–8129. doi: 10.1021/jacs.7b04937

Scheme 2.

Scheme 2

(a) Discovery and (b) SAR of CuH-catalyzed tandem hydroacylation and 1,4-reduction with unsaturated acyl electrophiles.a

a yields determined by 1H NMR analysis of crude reaction mixture, (S,S)-Ph-BPE = 1,2-Bis((2S,5S)-2,5-diphenylphospholano)ethane.