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Cell proliferation (A and B) and apoptosis (C and D) assays of HLE (A and C) and SNU-449 (B and D) cells treated with G007-LK, U0126 or MK-2206, either alone or in combination for 48 hours. Tukey-Kramer test: p<0.05 (a) vs. DMSO; (b) vs. 20μM G007-LK alone; (c) vs. 25μM U0126 alone; (d) vs. 5μM MK-2206 alone; (e) vs. G007-LK+U0126. Experiments were repeated three times in triplicate.
