Fig 6.

CA, RA, and CA + RA have no effect on HLF cell cycle at non-cytotoxic concentrations (A) and induce G0/G1 arrest at cytotoxic concentrations(B). In A, cells were treated with 5 μM RA, 2 μM CA, with combination 2.5 μM RA + 1 μM CA (RC) or with 1.5 μM mitomycin (M) for 24 hours. In B, cells were treated with 100 μM RA, 20 μM CA or with combination 100 μM RA + 20 μM CA (RC). Data are expressed as the percentage of cells in different cell cycle phases (G0/G1, S and G2/M) and are the mean values μ SD of three (A) and four (B) different experiments. **p = 0.01 vs C in G0/G1 phase, *p<0.05 vs C in G0/G1 phase, ^#p<0.05 vs C in S phase.