Figure 1. Schematic illustration summarizes the actin-based growth cone motility.
(a) Nerve growth cones protrude towards or retract from attractive or repulsive cues during guidance. (b) A representative fluorescent image of a rat hippocampal growth cone showing the actin-rich P-region (blue) and the microtubule-concentrated C-region (red). (c) he clutch model and the local enrichment of G-actin enable the forward movement of the growth cone. The right panel highlights that the propulsive force generated by Arp2/3-mediated intrapodia contributes to the generation of traction force for growth cone movement.