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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Mol Neurobiol. 2017 Mar 6;55(3):1998–2012. doi: 10.1007/s12035-017-0457-y

Fig. 4.

Fig. 4

a Trimethylation of histone H3 at lysine 27 (H3me3K27) of the 5-HT2A, 5-HT1A, and mGluR2 genes at the −1.4 kb upstream, promoter, and exon 1 regions in the prefrontal cortex (PFC). There was no acetylation of the histone H3 in any of the regions of the three genes. The gene of reference GAPDH showed acetylation of H3 at the promoter region, validating the chromatin immunoprecipitation assay (c). b When comparing the different regions within the same gene for H3me3K27 levels, the promoter region peaked significantly for all three genes. d When comparing individually the promoter region for differences in H3me3K27 levels between the two strains, no differences were observed for any of the three genes. Two-way ANOVA #p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001