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Average plasma pharmacokinetic parameters of cyclocreatine in male C57 mice (n=12) and male Sprague-Dawley (SD) rats (n=4) after oral administration (30 mg/kg).
| 30 mg/kg PO (C57 mice) | 30 mg/kg PO (SD rats) | |
|---|---|---|
| AUC0 → ∞ (μg h/mL) | 84.1 | 91.7 ± 18.0 |
| t(1/2) (h) | 6.6 | 7.9± 0.9 |
| Tmax (h) | 5 | 0.58±0.48 |
| Cmax (μg/mL) | 5.62 | 13.3±2.6 |
