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. Author manuscript; available in PMC: 2017 Nov 24.
Published in final edited form as: Nature. 2017 May 24;546(7657):248–253. doi: 10.1038/nature22394

Extended Data Figure 4. Resolution of cryo-EM map and validation of the hGLP-1:rGLP-1R:Gs structure.

Extended Data Figure 4

a, Resolution estimation of the EM map. “Gold standard” Fourier shell correlation (FSC) curves, showing the overall nominal resolution at 4.1 Å (blue) and 3.9 Å (red) on the stable region including hGLP-1, TM domain and GαsRas α5-helix. b, FSC curves of the final refined model versus the final cryo-EM map (full dataset, black), of the outcome of model refinement with a half map versus the same map (red), and of the outcome of model refinement with a half map versus the other half map (green). c, Final three-dimensional density map colored according to local resolution.