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a, GLP-1R:Gs complex structure docked into cryo-EM density map prior to density subtraction. Arrows indicate the density corresponding to the linker between NTD and TM bundle, and Gβγlipid moiety inserting into the detergent micelle. b, Close-up view in this map shows density connecting H8 and Gβ at the position of R419 of H8 and G310-H311 of Gβ. Model is colored as in Figure 1c.
