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. Author manuscript; available in PMC: 2017 Nov 24.
Published in final edited form as: Nature. 2017 May 24;546(7657):248–253. doi: 10.1038/nature22394

Extended Data Figure 9. Potential NTD-TM interaction, orthosteric agonist binding pocket in GLP-1R and β2AR.

Extended Data Figure 9

a, Close-up view of the model docked into cryo-EM density map (grey) on the region of NTD-TM at low threshold shows the potential hydrogen bond between Q213 of ECL1 and R40 of NTD α1-helix. b, Overlay of GPCR TM bundles in the activated GLP-1R complex and T4L-β2AR:Gs:Nb35 complex shown in light green and grey, respectively. Cut-through view showing that the GLP-1 peptide N-terminal H7 (orange ball and stick) reaches the same level as the orthosteric agonist BI-167107 (yellow).