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. 2017 Jul 1;25(13):3471–3482. doi: 10.1016/j.bmc.2017.04.037

Fig. 8.

Fig. 8

a) The crystal structure of 9, a hinge binding fragment, bound to CK2α. Met163 (green) is in the down position where it blocks the channel between the αD site and the ATP site. b) The structure of 9 superimposed onto the structure of 19 where Met163 (blue) is flipped up and opens the channel between the αD site and the ATP site. Met163 would in this position clash with ZT0432. c) The crystal structure of 8 bound to CK2α. Met163 (green) is in the down position where it blocks the channel between the αD site and the ATP site. d) The structure of 8 superimposed onto the structure of 19 where Met163 (blue) is flipped up and opens the channel between the αD site and the ATP site. Met163 does not clash with 8.