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. 2017 Jul 1;25(13):3471–3482. doi: 10.1016/j.bmc.2017.04.037

Scheme 1.

Scheme 1

(a) DMF, RX, Na2CO3, (b) i) LiAlH4, Et2O, AlCl3, ii) Et2O, 2 M HCl in Et2O. General procedures are detailed in the Supporting information.