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. 2017 Sep 6;7:10651. doi: 10.1038/s41598-017-11034-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kir7.1 channel blocker VU590 inhibits c-wave originating from RPE cell. (A) Representation of the scotopic traces at different intensities from control mice and mice injected with VU590 or VU-608, an inactive analogue of VU-590. (B) Amplitude of a-wave and (C) b-wave after VU590 injection (red) compared with the VU608 injected eye (blue) and the control (black) saline injected eye. (D) Scotopic ERG trace representing the reduction of c-wave after the injection of VU590 but not with VU608 when compare with control. (E) Graphical representation of the c-wave reduction after Kir7.1 channel inhibition. Data is mean ± SEM and *P < 0.005.