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. 2017 Sep 6;7:10651. doi: 10.1038/s41598-017-11034-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Optical Coherence Tomography imaging of saline (A) and shRNA (B) injected eyes to visualize the structural integrity of the RPE and retina. In both panels A and B, the fundus photo shown in the left panel indicates the orientation (arrow) of the cross-sectional OCT. The scanned images with the outer nuclear (ONL) and inner nuclear (INL) layers is highlighted in the panel on the right. In image B, GFP fluorescence is evident in the white patches. (C) Ex-vivo ERG allows recording the response from the retina, only. ERG traces from the retina before (black) and after the treatment with 50 µM VU590 (red) are shown. The proper functioning of the ERG and the retina is confirmed by the treatment with 100 µM Ba²⁺ (blue). (D) Bar graph representing the amplitude of a- and b-waves in ex-vivo ERG recording after treatment with VU590 and Ba²⁺ are shown as compared to control.