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. 2017 Sep 6;7:10651. doi: 10.1038/s41598-017-11034-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of Kir7.1 current by VU590. Representative traces of whole cell currents recorded from single isolated RPE cells from mouse (A) and CHO-K1 cells (B) overexpressing the Kir7.1 channel, respectively. Whole cell currents were recorded by voltage ramping from +40 mV to −160 mV. The traces represent current density, which is the whole cell current normalized for the cell capacitance. In both cell types, the normal baseline Kir7.1 current is recorded prior to cells being treated with 50 µM VU590. The current is reduced after treatment with VU590, but is not affected by the treatment with 50 µM VU608. (C) and (D) The normalized Kir7.1 current at −160 mV is compared before, and after, treatment with VU590 or VU608.