Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 6;7:10662. doi: 10.1038/s41598-017-11106-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Identification of AHR as a novel target of NR2E3 by RNA sequencing (RNA-seq) and bioinformatics analyses. (a) Gene set enrichment analysis by employing RNA-seq data derived from small hairpin RNA control (shCT) and NR2E3-depleted (shNR2E3) HepG2 cell RNA lysate showed that NR2E3 gene networks are associated with drug metabolism involving cytochrome p450 and metabolism of xenobiotics by cytochrome p450 signaling pathways. (b) Venn diagram revealed 252 differentially expressed genes (DEGs) commonly regulated by NR2E3 depletion in both MCF-7 and HepG2 cells (p < 0.0005). (c) Heat map of the 253 common genes indicates that AHR expression (red) is markedly downregulated in both MCF-7 and HepG2 cells. (d) WikiPathway analysis using the common gene set showed the association of NR2E3-regulated genes with AHR-related signaling pathways (FDR < 0.05).