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. 2017 Sep 6;7:10612. doi: 10.1038/s41598-017-10397-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MNK2 was overexpressed in NSCLC and correlated with poorer prognosis. (a) MNK2 was highly expressed in NSCLC tissues compared with normal adjacent lung tissues (NATs) (**P < 0.01). Representative IHC staining of MNK2 in 2 pairs (low expression and high expression) of NSCLC cases (original magnification: ×200). (b) RT-PCR analysis showed that MNK2 was overexpressed in most NSCLC cell lines compared with normal bronchi epithelial cell line (16HBE) (*P < 0.05, **P < 0.01). (c) Kaplan-Meier analysis showed that the overall survival (OS) rates of NSCLC patients with MNK2 overexpression were lower, especially in adenocarcinoma and clinical stage III + IV (P < 0.01).