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. 2017 Sep 6;7:10612. doi: 10.1038/s41598-017-10397-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Silencing of MNK2 increased cell apoptosis, reduced cell migration, invasion and promote metastasis in NSCLC. (a) Annexin-V/propidium iodide (PI) assay was performed to cell apoptosis between cells treated with siRNA-MNK2 and negative control. The representative images are shown (Left). Results were summarized as mean ± SD of 3 independent experiments (**P < 0.01) (Right). (b) Cell migration and invasion were performed to compare cell motilities between cells treated with siRNA-MNK2 and negative control cells. The representative images are shown (Left). Results were summarized as mean ± SD of 3 independent experiments (**P < 0.01) (Right). (c,d) Representative images of metastatic nodules on the liver surface of tested mice (Left). Visible tumor nodules on the liver of tested mice were compared between A549 (**P < 0.01) and NCI-H460 (*P < 0.05) cell groups.