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. 2017 Sep 6;7:10659. doi: 10.1038/s41598-017-09368-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Strong TCR signalling in DN cells of TCRδ^−/−. pTα^−/− mice promotes increased development of unconventional TCRαβ⁽⁺⁾CD8αα⁽⁺⁾ IELs. (A) Representative flow cytometry plots of DN3 and DN4 subsets from C57BL/6, pTα^−/− and TCRδ^−/−. pTα^−/− mice. Lower plots show surface TCRβ, and combined expression of Vα2, Vα8 and Vα11, on DN4 cells from each strain. (B) Representative (from n > 3) histogram of CD5 on CD122⁽⁻⁾TCRδ⁽⁻⁾ DN cells from pTα^−/− and TCRδ^−/−. pTα^−/− mice. (C) Representative flow cytometry plots and corresponding summary bar charts of TCRαβ⁽⁺⁾ IEL populations from C57BL/6, and pTα^−/−. TCRδ^−/− mice. Percentages of gated cells are indicated. ****p < 0.0001.