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. 2017 Sep 6;7:10656. doi: 10.1038/s41598-017-11152-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The concentration – intensity calibration curves obtained for simultaneous multiplexed detection of three IL-6, IL-8, and IL-18 interleukins from blood plasma samples. Each SERS spectrum was averaged from 20 measurements at different places across the SERS surface using the mapping mode. The error bars indicate the standard deviations from twenty measurements at different spots for each concentration.