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. 2017 Sep 6;7:10669. doi: 10.1038/s41598-017-10993-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Topology and sequence alignment of TRPV subunits. (a) Membrane topology of TRPV subunits. Red circles and red line indicate four point mutations and C-terminal deletion in TRPV6_cryst construct, respectively. (b) Sequence alignment of the transmembrane domain regions in rat TRPV subtypes. Helices are indicated by cylinders above the sequence. L495 (open red box) and the selectivity filter in TRPV6 (thick red line) are highlighted. ¥ marks the N-linked glycosylation site in the extracellular loop connecting S1 and S2 conserved in TRPV6 (and TRPV5) channels.