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. 2017 Sep 6;7:10681. doi: 10.1038/s41598-017-11031-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Crystal structure of CP525 elucidates the H19–C-terminal tail conformation. (A) Crystal structure of CP525 homo-tetramer. One monomer (Mol1) is highlighted in rainbow colors: colder colors from N-terminus and warmer colors to C-terminus. (B) CP525 structure seen from the left side of panel A to highlight the H19-C-terminal tail conformation. (C) Surface representation of CP525 structure from the same orientation with (B). Blue area, the interface between Mol1 and Mol3; purple area, the interface between Mol1 and Mol2. (D) Close-up view of H19 that serves as the interface between molecules 1 and 3 is shown. (E) Sequence alignment of H19 and C-terminal tail are shown with the interacting residues in the CRMP2 tetramer. The Structural detail of the C-terminal tail is described in Fig. S3. Basic residues in H19, blue background; hydrophobic residues in C-terminal tail, gray background.