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. 2017 Sep 6;7:10681. doi: 10.1038/s41598-017-11031-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Solution structure of CRMP2-GTP-tubulin hetero-trimer complex from small angle X-ray scattering. (A) Pair distance distribution functions (P(r)) and the Guinier plot. (B) Agreement of scattering data with GASBOR models (χavg = 2.21 ± 0.082). (C,D) Ribbon models of CRMP2 solved (C) and tubulin-dimer (PDB ID = 1JFF) (D) with size indication. (E) SAXS envelope for the CRMP2-tubulin complex. (F) Fitting of atomic models of CRMP2 and tubulin-dimer into the SAXS envelope. (G) Fitting of SAXS model of CRMP2-tubulin complex into the plus-end of the microtubule with 13 protofilaments (EMD-5195). (H) Close-up view of the dotted square in panel (G) depicts no steric clashes between neighboring CRMP2s. Data are mean ± s.d.