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. 2017 Sep 6;7:7499. doi: 10.1038/s41598-017-06975-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Variation in mass of different density fractions of a single CT slice during tidal ventilation in uninjured animals in different ventilation modes. During inspiration, atelectatic lung (dark grey) decreased marginally with a greater decrease in poorly aerated mass (light grey) and a reciprocal increase in normally aerated lung (white). Overdistended lung represented less than 0.1% of the mass of the slice and was excluded from the figure. Error bars represent SD at each time point. Panel subtitles indicate ventilation mode and I:E ratio. VC – volume control; PC – pressure control.