Table 2.
The clinicopathological characteristics related to the expression of APOBEC3A in the second cohort (n = 188)
| Patient categories | Case No. | APOBEC3A expression level | p-value | |
|---|---|---|---|---|
| Low (%) | High (%) | |||
| Gender | ||||
| Male | 172 | 87 (46.2) | 85 (45.2) | 0.794 |
| Female | 16 | 7 (3.72) | 9 (4.79) | |
| Age a | 51.2 ± 10.8 (80, 29) | 52.4 ± 10.0 (79, 30) | 0.327 | |
| pT status | ||||
| 1–2 | 87 | 39 (20.7) | 49 (26.1) | 0.109 |
| 3–4 | 100 | 56 (29.8) | 44 (23.4) | |
| pN status | ||||
| (−) | 97 | 42 (22.3) | 55 (29.2) | 0.079 |
| ( + ) | 91 | 52 (27.6) | 39 (20.7) | |
| Overall pathological stage | ||||
| I–II | 56 | 19 (10.1) | 37 (19.6) | 0.006b |
| III–IV | 132 | 75 (39.8) | 57 (30.3) | |
| ECS c | ||||
| (–) | 142 | 68 (36.1) | 74 (39.3) | 0.396 |
| (+) | 46 | 26 (13.8) | 20 (10.6) | |
| Cell differentiation d | ||||
| W-D + M-D | 163 | 78 (41.4) | 85 (45.2) | 0.197 |
| P-D | 25 | 16 (8.5) | 9 (4.7) | |
| Perineural invasion | ||||
| No | 103 | 44 (23.4) | 59 (31.3) | 0.027b |
| Yes | 85 | 50 (26.6) | 35 (18.6) | |
| Second primary occurrence | ||||
| No | 174 | 87 (46.2) | 87 (46.2) | 1.000 |
| Yes | 14 | 7 (3.72) | 7 (3.72) | |
| Bone invasion | ||||
| No | 137 | 61 (32.4) | 76 (40.4) | 0.013b |
| Yes | 51 | 33 (17.5) | 18 (9.57) | |
| Tumor depth a | 15.1 ± 10.0 (48, 1) | 14.9 ± 11.1 (55, 2) | 0.625 | |
aMean ± SD, median (maximum, minimum)
bStatistically significant
cECS: extracapsular spread
dW-D: well-differentiated, M-D: moderately-differentiated, and P-D: poorly-differentiated, squamous cell carcinoma