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. 2017 Sep 6;7:10637. doi: 10.1038/s41598-017-11283-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Global analysis of differentially expressed proteins. (A) Mean of log₂ I/C ratio distribution of intracellular modulated proteins. The red and blue dots represent up-regulated and down-regulated proteins, respectively. Shade gray area represent proteins involved in iron transport and metabolism. Dash lines indicate the upper and lower log2 ratio cutoff (0.24, −0.26) used to consider proteins as being modulated. Numbers located at the right, indicate the total number of up, down and non-modulated proteins identified in this study. (B) Distribution of the identified modulated proteins accordingly to their assigned functional category (COGs).