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. 2017 Sep 6;7:10586. doi: 10.1038/s41598-017-10973-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Prediction of collagen orientation angle in the superficial zone with a generalized model (a) and with the three condition-specific models (b). The average smoothed spectra of ICRS0, ICRS1 and ICRS2 (c) with the selected wavelengths (black regions) of IVS for each condition-specific model of superficial collagen orientation angle. Furthermore, differences in the spectra of the ICRS groups are highlighted in the 2^nd derivative average spectra (y-axes not in scale) within the mutual wavelength regions (I-IV).