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A schematic working model for the mechanisms of cisplatin resistance mediated by O-GlcNAcylation. Depending on the cellular context, O-GlcNAcylation targets either p53 or c-Myc in cisplatin-treated cells and interferes with its ubiquitin-mediated proteasomal degradation that causes either p53 degradation or c-Myc stabilization.
