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. 2017 Sep 6;7:10632. doi: 10.1038/s41598-017-10878-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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p53-dependent regulation of the expression of proteins involved in metabolism and functioning of thiamine by OT. Differentiated SH-SY5Y cells were treated with (a) 100 μM PT, OT and AM. THTR1, TK, PDHB, OGDH gene expression were determined by RT–PCR. (b) Differentiated SH-SY5Y cells were collected, electroporated with 1 μM of p53 decoy (wt) or nonsense oligonucleotide (nonsen) followed by treatment with 100 μM OT. THTR1, PDHB, OGDH gene expression were determined by RT–PCR. All presented data (a,b) were normalized to GAPDH and expressed as the percentages of increase over non-treated cells (−). One way ANOVA and Bonferroni post-testing (*P < 0.05, **P < 0.01, ***P < 0.001) indicates statistically significant differences between samples (n = 3).