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. 2017 Sep 6;7:10703. doi: 10.1038/s41598-017-11151-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conformational change in response to antagonist. (A) Changes in the minimum resonance position following incremental addition of CXCR3 agonist PS372424, or CXCR3 antagonist SCH546738 to HEK-CTRL, HEK-CXCR3-A and HEK-CXCR3-B cell fragments as a function of time obtained with p-(left panel) and s-(right panel) polarized lights. (B) PWR shifts obtained with p-(left panel) and s-(right panel) polarized lights for HEK-CXCR3-A and HEK-CXCR3-B after treatment of SCH546738 (1 h at 2.2 nM). (C) KD values for PS372424 or SCH546738 interaction with CXCR3-A in HEK-CXCR3-A and HEK-CXCR3-B cells. All the results represent three independent experiments combined to calculate mean and SEM, and values were normalized to those obtained for the control cells.