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. 2017 Jul 7;45(15):8697–8711. doi: 10.1093/nar/gkx587

Figure 7.

Figure 7.

Regulatory element enrichment analysis and KEGG pathway enrichment analysis using significant hypomethylated Alu/LINE-1 DMR. Significant enrichment indicates Alu and LINE-1 DMR that are more likely to appear in regulatory elements (A) or KEGG pathways (B). Hypomethylation of Alu and LINE-1 may involve in cis-regulatory changes and potential transcription activation events in cancer-related pathways in tumor tissues. DNase: DNase I hypersensitivity sites; TFBS: transcription factor binding sites; H2A.Z: histone H2A variant; H3: histone H3; H4: histone H4; K: lysine; me1: monomethylation; me2: demethylation; me3: trimethylation; ac: acetylation.