Figure 1.

Schematic overview of the MCbiclust pipeline. The schematic shows (i) the methods used to find a core bicluster how this process is repeated and compared by Silhouette analysis to identify the unique biclusters (upper panel); (ii) how these biclusters are then extended (middle panel); and (iii) functionally and structurally analyzed (lower panel). The overall description of the process is given in the Materials and Methods section, with full details of each step describes in Supplementary Methods. A key step in the bicluster analysis is the calculation of correlation vectors, which is further explained in Supplementary Figure S1.