Table 1. Glucose homeostasis at death in islets-grafted patients.
| Recipient | 001 | 002 | 003 | 004 |
|---|---|---|---|---|
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| Sex | Man | Man | Woman | Man |
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| Age at death | 43 | 46 | 43 | 55 |
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| Time postx (mo) | 22 | 17 | 50 | 60 |
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| Insulin requirement/day (U/Kg/day) | 0.54 | 0 | 0 | 0.7 |
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| HbA1c | 6.9 | 6.1 | 6.3 | 6.7 |
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| Fasting C-peptide (nmol/l) | 0.38 | 0.67 | 0.80 | 0.34 |
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| BMI | 26.4 | 25.2 | 20.7 | 24 |
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| Daclizumab | Daclizumab | Azathioprine | Daclizumab | |
| Immunosupression | Tacrolimus | Tacrolimus | Cyclosporin A | Tacrolimus |
| Sirolimus | Sirolimus | Prednisolone | Sirolimus | |
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| Smoking | No | No | No | No |
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| Hypertension | Controlled by therapy | Controlled by therapy | Controlled by therapy | Controlled by therapy |
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| Cause of death | Accident | Ml | Ml | Ml |
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| No. donor | 3 | 2 | 2 | 4* |
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| Sex | F+M+M | M+M | M+M | F+F/M/M |
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| Age | 32+41+52 | 50+53 | 27+44 | 64+60/58/54 |
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| BMI | 31.5+23.9+33.9 | 31.8+25.6 | 24.1+27.5 | 23+21.9/36.9/23.7 |
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| Cold ischemia time (hours) | 8+2.5+14 | 7.5+2 | <8+<8 | 6.2+7/10/8 |
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| Preservation solution | TLM+UW+TLM | TLM+UW | UW+UW | UW/UW/UW |
*
Patient 004 received islets from 4 different donors at the three time points 60, 56 and 6 months before death, Ml = Myocardial infarction, TLM = Two layer method, UW = University of Wisconsin solution, F=female, M=male