FIG 1 .

Identification of a STAT transcription factor signature in immune response against the Orsay virus (OrV) in C. elegans. (A) Schematic representation of known antiviral pathways in C. elegans. (B) MEME motif enrichment in genes regulated upon infection and conservation of the de novo-identified motif by Tom-tom. ID, identifier. (C) Schematic representation of conserved domains between the human STAT-1 and C. elegans STATs. The red bars depict the predicted phosphorylation sites (20). aa, amino acids. (D) Phylogenetic analysis of STAT transcription factors. Nematodes are indicated in blue, and vertebrates are indicated in red. Trichinella spiralis, Brugia malayi, Caenorhabditis briggsae, Drosophila melanogaster, Homo sapiens, and Strongylocentrotus purpuratus STATs are shown on the tree. The tree is based on full-length sequences. Alignment was performed with Muscle. Branch support values are from bootstrap using 1,000 iterations. Only values lower than 0.8 are depicted. The bar shows a branch length of 0.7 nucleotide substitutions per position.