FIG 2 .

STA-1 is a key transcription factor in the immune response upon Orsay virus (OrV) infection. (A, C, and D) Viral loads in different strains measured by RT-qPCR on the Orsay virus RNA1 genome after 3 days of infection. The wild-type (WT) control N2 strain, rde-1(ne219) strain, and strains with sta-1(ok587) and sta-2(ok1860) mutations were infected. Values that were significantly different (P < 0.01) from the value for the wild-type control strain (unless otherwise indicated) by a two-tailed Mann-Whitney U test are indicated with an asterisk. Values that were not significantly different (ns) are indicated. n = 6 for panels A and C, and n = 4 for panel D. (B) Expression of a single-copy transgene coding for a GFP::STA-1 fusion protein under the control of a sur-5 promoter in adult animals. DIC, differential interference contrast.