FIG 7 .

In vivo effect of CrtN and its inhibition by NP16. (A and B) Bacteria recovered from the spleens and livers of mice infected with the wild-type COL or COL-ΔcrtN strains. (C and D) Bacteria recovered from the spleens and livers of mice infected with the COL strain, with or without compound NP16 treatment. (E) Bacteria recovered from the kidneys of mice infected with clinical isolate strain AE052 or strain AE052-ΔcrtN. (F) Bacteria recovered from the kidneys of mice infected with strain AE052, with or without compound NP16 treatment. All data represent mean values ± the standard errors of the means. *, P < 0.05; **, P < 0.01; ***, P < 0.001. P values were determined using GraphPad Prism with an unpaired parametric t test and Welch’s correction.