Table 1.
Mice models of ciliary dysfunction and their phenotype.
| Phenotype | Reference | |
|---|---|---|
| Mediobasal hypothalamus KIF3A and IFT 88 knockdown |
↑ food intake | |
| ↓ energy expenditure | [32] | |
| ↓ anorexigenic effect of ICV injections of leptin/insulin/glucose | ||
|
| ||
| Systemic deletion KIF3A TG737 (IFT88) |
↑ body weight | |
| ↑ food intake | ||
| Hyperleptinemia | [2] | |
| Hyperinsulinemia | ||
| Fasting hyperglycemia | ||
|
| ||
| BBS knockout models Bbs2 −/− Bbs4 −/− Bbs6 −/− |
↑ body weight | |
| ↑ food intake | [33] | |
| ↓ locomotor activity | ||
| Hyperleptinemia | ||
|
| ||
| IFT88 Δ/Δ mice | ↑ body weight | [34] |
| Hyperleptinemia | ||
|
| ||
| CEP19 knockout | ↑ body weight | |
| Hyperphagia | [35] | |
| ↓ glucose tolerance | ||
| Insulin resistance | ||
|
| ||
| ANK RD26 knockout | ↑ Body weight | |
| Hyperphagia | [36] | |
| MCHR1 and SST3R mislocalization in the hypothalamus |
||
|
| ||
| TTC21B knockout | ↑ body weight (fat mass) | |
| Hyperleptinemia | [37] | |
| Hyperinsulinemia | ||
| ↓ glucose tolerance | ||
|
| ||
| Rpgrip 1L +/− | ↑ body weight (fat mass, lean mass) |
|
| Leptin resistance | [38] | |
| Altered production of hypothalamic neuropeptides | ||
|
| ||
| POMC-specific KIF3A KO |
↑ body weight | |
| ↑ food intake | [2] | |
| Hyperleptinemia | ||
| Hyperinsulinemia | ||