Table 6.

Deregulated miRNA in HBV infection or HBV-related disease.

MicroRNA	Alteration	Target	Citation
miR-1	Up	HDAC4, FXRA	[25]
miR-15a	Down	HBp and HBx	[26]
miR-15b	Down (early stage) Up (late stage)	HNF1α	[27]
miR-15a/16	Down	Bcl-2	[28]
miR-17	Up	ULK1, ATG7, p62	[29]
miR-17-92 cluster	Up	HBV transcripts, E2F1	[30, 31]
miR-18a	Up	ESR1, ERa	[29, 32]
miR-19b	Up	P53	[30]
miR-20a	Up	Egln3/PHD3	[30]
miR-21	Up	PDCD4, PTEN	[33]
miR-22	Down	CDKN1A, AKT3, p21	[34, 35]
miR-26b	Down	CHORDC1	[36]
miR-27a	Up	MAP2K4, TRβ1	[30]
miR-29a	Up	PTEN	[37]
miR-29c	Down	TNFAIP3	[38]
miR-33a	Up	Smad7	[21]
miR-34c	Down	TGIF2	[39]
miR-93	Down	MICA	[40]
miR-99a	Down	AGO2	[41]
miR-101	Down	FOXO1, EZH2, DNMT3A	[42–44]
miR-103	Up	PER3, CDK5R1	[29]
miR-106a	Up	P130, FAS	[29]
miR-107	Up	CDK8, let-7	[29]
miR-122	Down	HBV DNA polymerase, Cyclin G1, HO-1, NDRG3, PPARγ, PBF	[45–47]
miR-125a-5p	Up	HBsAg	[46, 48]
miR-125b	Down	SCNN1A	[22]
miR-125b-5p	Up	HBsAg, LIN28B/let-7 axis	[49, 50]
miR-126	Down	PI3KR2, Crk, PLK2	[30]
miR-130a	Down	PPARG, Era, PGC1α, PPARγ	[30, 45, 51]
miR-141	—	PPARα	[46]
miR-143	Up	FNDC3B	[47]
miR-145	Down	CUL5	[52]
miR-146a	Up	STAT1, CFH, RIG-I, RIG-G	[23, 46, 53]
miR-148a	Up	c-Met, Wnt	[30]
miR-152	Down	DNMT1	[46]
miR-155	Up	C/EBP, SOCS1	[46]
miR-181a	Up	HLA-A, E2F5	[46, 47]
miR-199a	Up	HBsAg	[46]
miR-205	Down	HBx	[46]
miR-210	Up	HBV pre-S1	[46]
miR-221	Up	PI3-K/Akt	[29]
miR-224	Up	HOXD10, CDC42, Smad4	[29, 47]
miR-331-3p	Up	ING5	[54]
miR-370	Down	NFIA	[45]
miR-372/373	Up	NFIB	[46]
miR-429	Down	NOTCH1	[55]
miR-449a	Up	CREBFXRA	[45]
miR-501	Up	HBXIP	[46]
miR-545/374a	Up	ESRRG	[29]
miR-548ah	Up	INFγR1	[46]
miR-581	Down	Dicer, EDEM1	[46]
miR-602	Down	RASSF1A	[29]
miR-939	Down	CEBPA	[45]
miR-1231	Up	HBcAg	[46]
miR-4717	Down	PD-1	[56]
Let-7a	Down	CCR7	[29]