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miR-184 directly targets the 3′UTR of IGF-1R. Luciferase assay in HEK293T cells co-transfected with miR-184 or NC and PGL3-IGF-1R-3′UTR WT or PGL3-IGF-1R-3′UTR Mut. miR-184 significantly suppressed the luciferase activity of PGL3-IGF-1R-3′UTR WT. However, the activity of the PGL3-IGF-1R-3′UTR Mut was not affected. *P<0.05 vs. NC. miR-184, miRNA-184; UTR, untranslated region; IGF-1R, insulin-like growth factor 1 receptor; NC, negative control; WT, wild-type; Mut, mutant.
