Table III.
Comparison of hemostatic parameters in patients with lung cancer and healthy controls, according to the type O and non-O blood groups.
| Patients with lung cancer | Healthy controls | |||||
|---|---|---|---|---|---|---|
| Variables | O (n=29) | Non-O (n=86) | P-value | O (n=34) | Non-O (n=64) | P-value |
| Age, years | 56.9±10.0 | 56.3±7.8 | 0.892 | 55.7±7.6 | 54.2±7.0 | 0.931 |
| Gender, male/female | 20/9 | 56/30 | 0.705 | 18/16 | 40/24 | 0.359 |
| BMI, kg/m2 | 22.1±2.4 | 22.3±8.0 | 0.802 | 22.4±3.0 | 23.5±2.4 | 0.751 |
| SBP, mmHg | 126.4±9.8 | 128.7±8.6 | 0.291 | 125.3±10.8 | 128.2±7.7 | 0.337 |
| DBP, mmHg | 79.1±6.5 | 80.7±6.8 | 0.347 | 76.7±9.1 | 79.5±6.4 | 0.265 |
| Smoking status, yes/no | 9/20 | 23/63 | 0.656 | 8/26 | 12/52 | 0.576 |
| Distant metastasis, yes/no | 13/16 | 42/44 | 0.709 | – | – | – |
| Hemoglobin, g/l | 128 (115–138) | 118 (104–134) | 0.140 | 143 (134–158) | 149 (136–161) | 0.359 |
| Platelet count, ×109/l | 227 (175–294) | 241 (179–322) | 0.604 | 212 (186–229) | 220 (200–242) | 0.083 |
| LDH, U/l | 180 (158–238) | 189 (157–230) | 0.879 | 125 (116–142) | 131 (120–141) | 0.745 |
| CEA, ng/ml | 4.8 (2.4–30.2) | 13.6 (4.2–43.9) | 0.088 | 1.4 (1.0–2.0) | 1.7 (1.0–2.5) | 0.134 |
| D-dimer, µg/l FEU | 759 (492–1,689) | 873 (406–2,349) | 0.828 | 78 (55–176) | 121 (63–256) | 0.298 |
| Fibrinogen, g/l | 3.6 (2.8–4.7) | 4.1 (3.1–4.9) | 0.440 | 2.1 (2.0–2.5) | 2.6 (2.1–2.8) | 0.004a |
| VWF,U/l | 1,190 (892–1,865) | 1,676 (1,099–2,383) | 0.022a | 865 (583–1,291) | 1,117 (772–1,649) | 0.006a |
| ADAMTS-13, U/l | 1,586 (1,087–1,890) | 1,333 (974–1,576) | 0.101 | 1,572 (1,397–2,239) | 1,403 (1,116–1,771) | 0.032a |
| FVIII, % | 130 (113–161) | 145 (124–194) | 0.014a | 98 (81–113) | 112 (100–124) | 0.003a |
a
P<0.05. Values are presented as the mean ± standard deviation or the median with interquartile ranges in parentheses. BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure; LDH, lactate dehydrogenase; CEA, carcinoembryonic antigen; FEU, fibrinogen equivalent units; VWF, von Willebrand factor; ADAMTS-13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif13; FVIII, factor VIII.