Table I.
Classification and characteristics of endometrial cancer [modified from (13)].
| POLE (ultramutated) | MSI (hypermutated) | Copy number low | Copy number high | |
|---|---|---|---|---|
| Frequency | 7.3% | 28.0% | 38.8% | 25.9% |
| Copy number aberrations | Low | Low | Low | High |
| MSI status | Mixed | High | Stable | Stable |
| Mutation rate | Very high 232×106 | High 18×106 | Low 2.9×106 | Low 2.3×106 |
| mutations/Mb | mutations/Mb | mutations/Mb | mutations/Mb | |
| Genes commonly mutated | POLE (100%) | PTEN (88%) | PTEN (77%) | TP53 (92%) |
| PTEN (94%) | RPL22 (37%) | CTNNB1 (52%) | PPP2R1A (22%) | |
| PIK3CA (71%) | KRAS (35%) | PIK3CA (53%) | PIK3CA (47%) | |
| PIK3R1 (65%) | PI3CA (54%) | PIK3R1 (33%) | ||
| FBXW7 (82%) | PIK3R1 (40%) | ARID1A (42%) | ||
| ARID1A (76%) | ARID1A (37%) | |||
| KRAS (53%) | ||||
| ARID5B (47%) | ||||
| Histological type | Endometrioid | Endometrioid | Endometrioid | Endometrioid, Serous, mixed |
| Tumor grade | Mixed (grade 1–3) | Mixed (grade 1–3) | Grade 1 and 2 | Grade 3 |
| Progression-free survival | Good | Intermediate | Intermediate | Poor |
Mb, megabase.