Table A.1.

Relative bias and RMSE of log-odds ratio^a estimates evaluated from N = 400 individuals with exposures pooled in pairs, g = 2, matched on a primary outcome, O1, and pooled randomly on a secondary outcome, O2, at Q1 = 0.288 and Q3 = 1.39 of the healthy population^b.

a	d	α1	β1		Relative bias		RMSE
					With O1c	Without O1d	With O1c	Without O1d
0.7	0.7	1.5	0.5	logOR(Q1) = 1.249	0.026	0.018	0.352	0.306
				logOR(Q3) = 0.772	0.013	0.047	0.156	0.156
0.9	0.9	1.5	0.5	logOR(Q1) = 1.249	0.024	0.024	0.304	0.294
				logOR(Q3) = 0.772	0.015	0.040	0.132	0.135
0.2	0.9	1.5	0.5	logOR(Q1) = 1.249	0.080	0.077	0.521	0.473
				logOR(Q3) = 0.772	0.043	0.036	0.189	0.140

^alogOR(x) is the log-odds ratio of O2 based on change in exposure, x.

^bHealthy population assumed gamma distribution with α₀ = 1 and β₀ = 1 for all simulations.

^cEstimators based on Eq. (5), ignoring O1 and using information on O2.

^dEstimators based on Eq. (A.3), which uses information on O1.