Figure 5.

Comparison of the putative proteins encoded by LAPMTB4*1 and LAPTM4B*2. Partial sequences of exon 1 are demonstrated. The nucleotide sequences are numbered with the putative transcription start site designated as +1. In-frame stop codons are underlined and marked with a hash symbol. The 19 bp sequences in both alleles are underlined. Owning to in-frame stop codons at nucleotide 40 and 103, mRNA of LAPTM4B*1 that only begin translation at nucleotide 157. However, LAPTM4B*2 may initiate translation at nucleotide 17, which would produce an extra 53 amino acids, indicated by letters underscored with the dotted line at N-terminus of LAPTM4B. LAPTM4B, lysosome-associated protein transmembrane 4-β.