Table II.
Genotype and allelic frequencies of LAPTM4B gene polymorphism in PTC patients and controls.
| LAPTM4B status | Healthy controlsa, n (%) n=697 | PTC, n (%) n=183 | Odds ratiob (95% CI) | P-value |
|---|---|---|---|---|
| Allele | ||||
| *1 | 1,058 (75.9) | 253 (69.1) | ||
| *2 | 336 (24.1) | 113 (30.9) | 1.516 (1.140–2.017) | 0.004 |
| Genotype | ||||
| *1/1 | 397 (57.0) | 90 (49.2) | ||
| *1/2 | 264 (37.8) | 73 (39.9) | 1.352 (0.919–1.987) | 0.125 |
| *2/2 | 36 (5.2) | 20 (10.9) | 2.765 (1.384–5.524) | 0.004 |
a
Data were analyzed by non-conditional logistic regression analysis.
b
Adjusted for age and sex. LAPTM4B, lysosome-associated protein transmembrane 4-β; PTC, papillary thyroid carcinoma; CI, confidence interval.