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. 2017 Jun 30;14(3):3177–3184. doi: 10.3892/ol.2017.6501

Figure 4.

Figure 4.

Overexpression of SIRT1 counteracted the miR-494-mediated tumor-suppressing effects in OVCAR3 cells. (A) Upregulation of SIRT1 in OVCAR3 cells was evaluated by western blot analysis, with β-actin used as a control. (B) Overexpression of SIRT1 reversed the inhibitory effect in proliferation mediated by miR-494 in OVCAR3 cells. (C) OVCAR3 cells' migration and invasion abilities were restored with a forced miR-494 expression and SIRT1 restoration. *P<0.05 compared with their respective controls. Data represents the mean ± or + standard deviation. SIRT1, sirtuin 1; miR, microRNA; Vec, vector.