Fig 1 Time frame of cohort study with examples of exposure during follow-up for three patients. *Death from any cause (other than oral streptococcal infective endocarditis), or admission to hospital for prosthetic heart valve or replacement of prosthetic heart valve, or lost to follow-up, or follow-up until December 2014. Participant A was exposed to an invasive dental procedure during follow-up, but did not present with oral streptococcal infective endocarditis. Participant B was exposed to both a non-invasive and an invasive dental procedure during follow-up and presented with oral streptococcal infective endocarditis; during the co-exposure period, priority was given to exposure of an invasive dental procedure. Participant C was not exposed to any dental procedure during follow-up and presented with an oral streptococcal infective endocarditis