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Molecular mechanism representation by which ROS assists apoptosis by inducing DNA damage in human NSCLC cells. Teroxirone sensitizes p53-dependent NSCLC cells to apoptosis via ROS-inducing mechanisms. ROS, reactive oxygen species; NSCLC, non-small cell lung cancer cells; Akt, protein kinase B; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein. p53, tumor protein 53; PARP, poly ADP-ribose polymerase; ΔΨm, mitochondrial membrane potential.
