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. 2017 Jul 20;14(3):3760–3766. doi: 10.3892/ol.2017.6637

Figure 3.

Figure 3.

MiR-381 inhibited the EMT of SGC-7901 cells through targeting SOX4. (A) miR-381 overexpression significantly decreased SOX4 mRNA and protein expression. (B) Patients in miR-381 low expression group got high SOX4 protein expression levels. (C) The wild type and mutant type commentary sequences of SOX4 3′-UTR for miR-381. (D) miR-381 only decreased the luciferase activity that carried wild type but not mutant type 3′-UTR of SOX4. (E) Overexpression of miR-381 significantly increased E-cadherin expression while decreased N-cadherin and vimentin expression in SGC-7901 cells. (A-E) Tests were repeated in triplicate with similar results. *P<0.05; **P<0.01.