Figure 1.
ATO reduced cell viability, induced phosphatidylserine externalization and mitochondrial membrane depolarization in SK-MES-1 cells. (A) SK-MES-1 and SW900 cells were sensitive to ATO treatment with IC50 values of 2.5 and 5 µM respectively. H520 and H2170 cells were relative resistance to ATO. (B) ATO increased the percentage of cells undergoing apoptosis in SK-MES-1 cells in a dose-dependent manner. (C) ATO increased the proportion of cells undergoing mitochondrial membrane depolarization in SK-MES-1 cells in a dose-dependent manner. Results were measured in triplicate experiments. *P<0.05, compared with the control group. ATO, arsenic trioxide; IC50, half-maximal inhibitory concentration.